Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review
Abstract
Bovine viral diarrhea virus (BVDV), a member of the genus Pestivirus of the family Flaviviridae, causes significant losses in cattle farming worldwide because of reduced milk production, increased mortality of young animals and reproductive, respiratory and intestinal problems. The virus is characterized by an important genetic, and consequently antigenic and pathogenic diversity. Knowing the variability of viral strains present in a population provides valuable information, particularly relevant for control programs development, vaccination recommendations and even identification of likely infection sources. Such information is therefore important at both local and regional levels. This review focuses on the genetic diversity of BVDV isolates infecting cattle in Spain over the last years. According to the published data, the most prevalent BVDV group in Spain was 1b, and to a lesser extent 1d, 1e and 1f. Besides, BVDV-2 has also been found in Spain with several ratified isolates. The studies carried out in Spain also showed increased genetic heterogeneity of BVDV strains, possibly due to a more intensive use of analytical tools available, presenting studies with increasingly greater sample sizes.Downloads
References
Aduriz G, Atxaerandio R, Cortabarria N, 2015. First detection of bovine viral diarrhea virus type 2 in cattle in Spain. Veterinary Record Open.
Alpay G, Weşilag K, 2015. Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1). Vet Microbiol 175: 1-6. https://doi.org/10.1016/j.vetmic.2014.10.034
Arias P, Orlich M, Prieto M, Cedillo Rosales S, Thiel HJ, Alvárez M, Becger P, 2003. Genetic heterogeneity of bovine viral diarrhea viruses from Spain. Vet Microbiol 96: 327-336. https://doi.org/10.1016/j.vetmic.2003.09.009
Barros SC, Ramos F, Pauperi S, Thompson G., Fevereiro M, 2006. Phylogentic analysis of Portuguese bovine viral diarrhea virus. Virus Res 18: 192-195. https://doi.org/10.1016/j.virusres.2005.12.009
Becher P, Orlich M, Shannon AD, Horner G, König M, Thiel HJ, 1997. Phylogenetic analysis of pestiviruses from domestic and wild ruminants. J Gen Virol 78, 1357–1366. https://doi.org/10.1099/0022-1317-78-6-1357
Becher P, Orlich M, Thiel HJ, 1998. Complete genomic sequence of border disease virus, a pestivirus from sheep. J Virol 72: 5165–5173.
Booth RE, Thomas CJ, El-Attar LMR, Gunn G, Brownlie J, 2013. A phylogenetic analysis of Bovine Viral Diarrhea Virus (BVDV) isolates from six different regions of the UK and links to the animal movement data. BMC Vet Res 44: 43. https://doi.org/10.1186/1297-9716-44-43
Carman S, van Dreumel T, Ridpath J, Hazlett M, Alves D, Dubovi E, Tremblay R, Bolin S, Godkin A, Anderson N, 1998. Severe acute bovine viral diarrhea virus infection in Ontario, 1993-1995. J Vet Diagn Invest 10: 27-35. https://doi.org/10.1177/104063879801000106
Deng M, Ji S, Fei W, Raza S, He C, Chen Y, Chen H, Guo A, 2015. Prevalence study and genetic typing of bovine viral diarrhea virus (BVDV) in four bovine species in China. PLOS ONE 10: e0121718 https://doi.org/10.1371/journal.pone.0121718
Diéguez FJ, Eiras C, Sanjuán ML, Vilar M, Arnaiz I, Yus E, 2008. Variabilidad genética del virus de la diarrea vírica bovina (BVDV) en Galicia. Producción Animal 239: 4-7.
Diéguez FJ, Yus E; Eiras C, Sanjuán ML, Cerviño M, Arnaiz I, 2016. Genetic diversity of bovine viral diarrhea virus and frequency of genotypes and subtypes in Galicia (NW Spain). Proc XXIX World Buiatrics Congress, Dublin (Ireland), July 3-8. p. 310.
Esperón F, Elvira L, de la Torre A, Delicado V, Álvarez M, 2016. Molecular epidemiology of bovine viral diarrhoea virus (BVDV) in Spain between 2007 and 2015, spatial and temporal distribution. Proc XXIX World Buiatrics Congress, Dublin. (Ireland), July 3-8. p: 373.
Fernandez-Aguilar X, Lopez-Olvera JR, Marco I, Rossel R, Colom-Cadena A, Soto-Heras S, Lavín S, Cabezón O, 2016. Pestiviurs in alpine wild ruminants and sympatric livestock from the Cantabrian Mountains, Spain. Vet Rec 178: 586. https://doi.org/10.1136/vr.103577
Fulton RW, Ridpath JF, Ore S, Confer AW, Saliki JT, Bruge LJ, Payton ME, 2005. Bovine viral diarrhea virus (BVDV) subgenotypes in diagnostic laboratory accessions: distribution of BVDV1a, 1b and 2a subgenotypes. Vet Microbiol 111: 35-40. https://doi.org/10.1016/j.vetmic.2005.10.002
Gethmann J, Homeier T, Holsteg M, Schirrmier H, SaBerath M, Hoffmann B, Beer M, Conraths F, 2015. BVDV-2 outbreak leads to high losses in cattle farms in Western Germany. Heliyon 1: e00019 https://doi.org/10.1016/j.heliyon.2015.e00019
Giammarioli M, Ceglie L, Rossi E, Bazzucchi M, Casciari C, Petrini S, de Mia JM, 2015. Increased genetic diversity of BVDV-1: recent finding and implications thereof. Virus Genes 50: 147-151. https://doi.org/10.1007/s11262-014-1132-2
Giangaspero M, Harasawa R, 2004. Genetic variety of Bovine viral diarrhea virus 2 strains isolated from sheep. J Vet Med Sci 66: 323-326. https://doi.org/10.1292/jvms.66.323
Houe H, 2003. Economic impact of BVDV infection in dairies. Biologicals 31: 137-143. https://doi.org/10.1016/S1045-1056(03)00030-7
Hurtado A, García-Pérez AL, Aduriz G, Juste RA, 2003. Genetic diversity of ruminant pestiviruses from Spain. Virus Res 92: 67-73. https://doi.org/10.1016/S0168-1702(02)00315-5
Jackova A, Novackova M, Pelletier C, Audeval C, Gueneau E, Haffar A, Petitt E, Rehby L, Vilcek S, 2008. The extended genetic diversity of BVDV-1: Typing of BVDV isolates from France. Vet Res Commun 32: 7-11. https://doi.org/10.1007/s11259-007-9012-z
Letellier C, Pardon B, van der Heyden S, Deprez P, 2010. Circulation in Belgium of a bovine viral diarrhoea virus type 2 closely related to North American hypervirulent viruses. Vet Rec 166: 625-627. https://doi.org/10.1136/vr.b4792
Luzzago C, Ebranati E, Sassera D, lo Presti A, Lauzi S, Gabanelli E, Ciccozzi M, Zehender J, 2012. Spatial and temporal reconstruction of bovine viral diarrea virus genotype 1 dispersion in Italy. Infect Genet Evol 12: 324-331. https://doi.org/10.1016/j.meegid.2011.12.007
Maris J, 2016. Case report: severe loss on a Belgian dairy farm presumably caused by an infection of Bovine viral diarrhea virus type 2a. Proc XXIX World Buiatrics Congress, Dublin (Ireland), July 3-8. pp. 314-315.
Olafson P, Maccullum AD, Fox FH, 1946. An apparently new transmissible disease of cattle. J Am Vet Medic Associ 163: 1165-1167.
Pellerin C, van den Hurk J, Lecomte J, Tussen P, 1994. Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortalities. Virology 203: 260-268. https://doi.org/10.1006/viro.1994.1483
Polak MP, Kuta A, Rybaltowski W, Rola J, Larska M, Zmudzi’nski JF, 2014. First report of bovine viral diarrhoea virus-2 infection in cattle in Poland. Vet J 202: 643-645. https://doi.org/10.1016/j.tvjl.2014.09.026
Ridpath JF, Bolin SR, Dubovi EJ, 1994. Segregation a bovine viral diarrhea virus into genotypes. Virology 205: 66-74. https://doi.org/10.1006/viro.1994.1620
Ridpath JF, Neill JD, Frey M, Landgraf JG, 2002. Phylogenetic, antigenic and clinical characterization of type 2 BVDV from North America. Vet Microbiol 77: 145-155. https://doi.org/10.1016/S0378-1135(00)00271-6
Ridpath JF, Gayla L, Neill JD, Hairgrove TB, Velayudhan B, Mock R, 2011. Change in predominance of bovine viral diarrhea virus subgenotypes among samples submitted to diagnostic laboratory over 20-year time spam. J Vet Diagn Invest 23: 185-193. https://doi.org/10.1177/104063871102300201
Rodriguez-Prieto V, Kukielka D, Rivera-Arroyo B, Martínez-López B, de las Heras AI, Sánchez-Vizcaíno JM, Vicente J, 2016. Evidence of shared bovine viral diarrhea infections between red deer and extensively raised cattle in south-central Spain. BMC Vet Res 12: 11. https://doi.org/10.1186/s12917-015-0630-3
Tajima M, Frey HR, Yamato O, Meade Y, Moening V, Scholz H, 2001. Prevalence of genotypes 1 and 2 of bovine viral diarrhea virus in Lower Saxony, Germany. Virus Res 76: 31-42. https://doi.org/10.1016/S0168-1702(01)00244-1
Tautz N, Elbers K, Stoll D, Meyers G, Thiel HJ, 1997. Serine protease of pestiviruses: determination of cleavage sites. J Virol 71: 5415–5422.
Vilcek S, Herring AJ, Herring JA, Nettleton PF, Lowings JP, Paton DJ, 1994. Pestiviruses isolated from pigs, cattle and sheep can be allocated into at last three genogroups using polymerase chain reaction and restriction endonuclease analyisis. Arch Virol 136: 309-323. https://doi.org/10.1007/BF01321060
Vilcek S, Paton DJ, Durkivic B, Strojny L, Ibata G, Moussa A, Loitsch A, Rosmanith W, Vega S, Scicluna MT, Paifi V, 2001. Bovine viral diarrhea virus genotype 1 can be separated into at least eleven genetic groups. Arch Virol 146: 99-115. https://doi.org/10.1007/s007050170194
Wakeley PR, Turner JLE, Ibata G, King DP, Sandvik T., Howard P, Drew TW, 2004. Characterisation of a type 2 bovine viral diarrhoea virus isolated from cattle in the UK. Vet Microbiol 102: 19-24. https://doi.org/10.1016/j.vetmic.2004.05.005
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