Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review

  • Francisco J. Diéguez Universidad de Santiago de Compostela, Facultad de Veterinaria de Lugo, Dept. Anatomía y Producción Animal. Campus Universitario s/n, 27002 Lugo
  • Manuel Cerviño Boehringer Ingelheim España S.A., Prat de la Riba 50, 08174 Sant Cugat del Vallès, Barcelona
  • Eduardo Yus Universidad de Santiago de Compostela, Facultad de Veterinaria de Lugo, Unidad de Epidemiología y Sanidad Animal del Instituto de Investigación y Análisis Alimentarios. Campus Universitario s/n, 27002 Lugo
Keywords: BVDV-1, BVDV-2, genetic groups, evolution, cattle


Bovine viral diarrhea virus (BVDV), a member of the genus Pestivirus of the family Flaviviridae, causes significant losses in cattle farming worldwide because of reduced milk production, increased mortality of young animals and reproductive, respiratory and intestinal problems. The virus is characterized by an important genetic, and consequently antigenic and pathogenic diversity. Knowing the variability of viral strains present in a population provides valuable information, particularly relevant for control programs development, vaccination recommendations and even identification of likely infection sources. Such information is therefore important at both local and regional levels. This review focuses on the genetic diversity of BVDV isolates infecting cattle in Spain over the last years. According to the published data, the most prevalent BVDV group in Spain was 1b, and to a lesser extent 1d, 1e and 1f. Besides, BVDV-2 has also been found in Spain with several ratified isolates. The studies carried out in Spain also showed increased genetic heterogeneity of BVDV strains, possibly due to a more intensive use of analytical tools available, presenting studies with increasingly greater sample sizes.


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How to Cite
Diéguez, F. J., Cerviño, M., & Yus, E. (2017). Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review. Spanish Journal of Agricultural Research, 15(2), e05R01.
Animal health and welfare